Glossary · Definition
ApoB (Apolipoprotein B)
ApoB (Apolipoprotein B) measures the count of atherogenic particles in your blood — the particles that drive atherosclerosis. Better predictor of cardiovascular disease risk than LDL cholesterol.
Definition
ApoB (Apolipoprotein B) measures the count of atherogenic particles in your blood — the particles that drive atherosclerosis. Better predictor of cardiovascular disease risk than LDL cholesterol.
What it means
Every atherogenic particle (LDL, VLDL, IDL, lipoprotein(a)) carries exactly one ApoB. So measuring ApoB tells you the COUNT of particles, while LDL-C tells you the cholesterol carried inside them. Two people with identical LDL-C can have very different particle counts and very different CV risk. ApoB is more predictive — the European Society of Cardiology and many US lipidologists now prefer it.
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Why it matters
If you've had a 'normal LDL' but a family history of heart disease, ask for an ApoB test. It's a simple add-on to your standard lipid panel ($25-50). Targets: under 90 mg/dL for general population, under 80 for people with CV risk factors, under 60 for active CV disease.
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Frequently asked questions
Is it covered by insurance?
Often yes if your doctor orders it. Worth asking — Quest and Labcorp both offer it routinely. Costs ~$25-50 self-pay.
What lowers ApoB?
Same things that lower LDL: diet (less saturated fat, more fiber), exercise, weight loss, statins, PCSK9 inhibitors. ApoB tracks closely with LDL but adds precision.